My brother brought me Dr. William Davis' book Wheat Belly some years ago. I read it all, and just thought, "Well, this is another fad for someone to propose and rake in some cash." But after studying about cholesterol and watching quite a few prominent people on YouTube, I really believe Dr. Davis knows what he is talking about.
Aside from just weight issues, I can vouch for the fact that when I don't eat wheat products, the arthritis in my knees doesn't flare.
If you're interested, watch the video linked below.